UNC1215
UNC 1215
CAS: 1415800-43-9
Molecular Formula: C32H43N5O2
UNC1215 - Names and Identifiers
| Name | UNC 1215 |
| Synonyms | CS-714 UNC1215 UNC 1215 UNC1215 UNC-1215 N-Phenyl-2,5-bis({[4-(pyrrolidin-1-yl)piperidin-1-yl]carbonyl})aniline (2-(phenylaMino)-1,4-phenylene)bis((4-(pyrrolidin-1-yl)piperidin-1-yl)Methanone) 1,1'-[2-(Phenylamino)-1,4-phenylene]bis[1-[4-(1-pyrrolidinyl)-1-piperidinyl]methanone] |
| CAS | 1415800-43-9 |
UNC1215 - Physico-chemical Properties
| Molecular Formula | C32H43N5O2 |
| Molar Mass | 529.72 |
| Density | 1.224±0.06 g/cm3(Predicted) |
| Boling Point | 712.1±60.0 °C(Predicted) |
| Solubility | DMSO: soluble5mg/mL, clear |
| Appearance | powder |
| Color | white to beige |
| pKa | 9.90±0.20(Predicted) |
| Storage Condition | 2-8°C |
| In vitro study | UNC1215 binds to L3MBTL3 and competitively replaces a peptide containing mono-or dimethyl lysine. This probe is 50-fold more selective than acting on other human MBT family members. UNC1215 was approximately 75-fold more selective for L3MBTL3 than for l3mbtl1. At concentrations as high as 30 μm, UNC1215 had no activity on the tandem Tudor domain of UHRF1, the chromatin domain of CBX7, and the PHD domain of JARID1A. X-ray crystallography revealed a unique 2:2 polymodal interaction between UNC1215 and L3MBTL3. UNC1215 is non-toxic to cells, binding directly to L3MBTL3 via the Kme binding pocket of the MBT domain. UNC1215 increases cell mobility and point mutation of GFP-L3MBTL3 fusion protein, interferes with Kme binding function of GFP-L3MBTL3 phenotype simulation, and affects the localization of UNC1215. UNC1215 was used to reveal a novel Kme-dependent L3MBTL3 interaction with BCLAF1, a protein closely related to DNA damage repair and apoptosis. |
UNC1215 - Risk and Safety
| WGK Germany | 3 |
UNC1215 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.888 ml | 9.439 ml | 18.878 ml |
| 5 mM | 0.378 ml | 1.888 ml | 3.776 ml |
| 10 mM | 0.189 ml | 0.944 ml | 1.888 ml |
| 5 mM | 0.038 ml | 0.189 ml | 0.378 ml |
Last Update：2024-01-02 23:10:35
UNC1215 - Introduction
UNC 1215 is a compound whose full name is N-(4-(dand-3-o-phenyl) phenyl) acrylamide. The following is a description of the nature, use, method and safety information of UNC 1215:
Nature:
-Appearance: UNC 1215 is usually a colorless or light yellow solid.
-Solubility: UNC 1215 can be dissolved in organic solvents, such as dimethyl sulfoxide and dimethylformamide.
-Melting point: The melting point of UNC 1215 is about 119-121°C.
Use:
-Research Field: UNC 1215 is commonly used in biomedical research, especially related to histone deacetylation.
-Anti-tumor activity: UNC 1215 is found to have anti-tumor activity, so it is widely used in the field of tumor treatment.
Preparation Method:
The preparation of-UNC 1215 usually adopts organic synthesis methods, and the specific steps may be slightly different, but it generally includes the reaction of the corresponding reactant and solvent under appropriate conditions, an extraction or purification step is performed to obtain the final product.
Safety Information:
The safety data of-UNC 1215 is very limited, so when using or handling, it is necessary to operate in accordance with the corresponding laboratory safety regulations.
-Avoid direct contact with skin, eyes and mucous membranes, and wear chemical protective clothing, goggles and gloves when necessary.
-If discomfort is caused by accidental inhalation or contact, seek medical help immediately and provide the product label or technical instructions to the doctor.
- UNC 1215 should be stored in a dry, cool, well-ventilated place, away from fire and heat sources.
Nature:
-Appearance: UNC 1215 is usually a colorless or light yellow solid.
-Solubility: UNC 1215 can be dissolved in organic solvents, such as dimethyl sulfoxide and dimethylformamide.
-Melting point: The melting point of UNC 1215 is about 119-121°C.
Use:
-Research Field: UNC 1215 is commonly used in biomedical research, especially related to histone deacetylation.
-Anti-tumor activity: UNC 1215 is found to have anti-tumor activity, so it is widely used in the field of tumor treatment.
Preparation Method:
The preparation of-UNC 1215 usually adopts organic synthesis methods, and the specific steps may be slightly different, but it generally includes the reaction of the corresponding reactant and solvent under appropriate conditions, an extraction or purification step is performed to obtain the final product.
Safety Information:
The safety data of-UNC 1215 is very limited, so when using or handling, it is necessary to operate in accordance with the corresponding laboratory safety regulations.
-Avoid direct contact with skin, eyes and mucous membranes, and wear chemical protective clothing, goggles and gloves when necessary.
-If discomfort is caused by accidental inhalation or contact, seek medical help immediately and provide the product label or technical instructions to the doctor.
- UNC 1215 should be stored in a dry, cool, well-ventilated place, away from fire and heat sources.
Last Update：2024-04-09 20:49:11
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Product Name: UNC 1215 Visit Supplier Webpage Request for quotation
CAS: 1415800-43-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 1415800-43-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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